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The U.S. Food and Drug Administration has approved Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) as treatment choice for chronic weight loss in addition to a reduced-calorie diet and physical activity.

Using two separate drugs to shed weight can be very effective there are combinations as you're watching FDA now awaiting approval. When dealing with weight loss and the people that go through it you need to err on the side of caution and allow FDA do its job and demand some investigation be done so your public recognizes the side effects and hazards of the medications before we take them. Keep in mind that drug companies come in business to make money and that they would say almost anything to keep people on their own medications.

Researchers discovered that participants investing in this drug for a year, dropped a few pounds within four weeks and have kept the weight off through the 56 weeks with the study. Contrave is often a combination of the drugs naltrexone and bupropion, which usually reflect a whole new trend of weight-loss drugs which might be made up of many active ingredient, which can make them more potent and safer.

Combo-pilling is the newest fad or even better the newest ahead under scrutiny and thus it is just more publicly known although in the past, comb-pilling for weight reduction has been around since the eighties. The biggest reason that employing a combination of pills is becoming popular will be the fact that at the time of right now there are no long term prescription slimming capsules that have been approved by the FDA other than orlistat. The truly disturbing part is doctors are prescribing these combinations of medications however some of the combinations are actually rejected or have yet to be licensed by the FDA.

Seizures certainly are a side effect with Contrave and shouldn't be taken in individuals with seizure disorders. The drug could also raise blood pressure level and heartbeat, and shouldn't be used in people who have a history of heart attack or stroke in the previous six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy with all the drug.

The FDA also warned that Contrave can raise blood pressure and pulse rate and must stop used in patients with uncontrolled high blood pressure level, as well as by you are not heart-related and cerebrovascular (blood vessel dysfunction impacting the brain) disease. Patients using a history of cardiac arrest or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes which has a boxed warning to alert health care professionals and patients to the increased chance of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for stop smoking.


"This could be the first drug I'm aware of that targets the appetite and reward centres in the brain," he was quoted saying.